Thursday, June 30, 2011

Loratadine and Desloratadine Use in Children

From Pediatric Pharmacotherapy

Marcia L. Buck, Pharm.D., FCCP, FPPAG
Posted: 06/17/2011; Pediatr Pharm. 2011;17(5) © 2011 Children's Medical Center, University of Virginia

http://www.medscape.com/viewarticle/743960_7  for full article
 
Introduction Loratadine is one of the most widely used antihistamines in the United States. Introduced on April 12, 1993 as a prescription medication for the treatment of perennial or seasonal allergic rhinitis and chronic idiopathic urticaria, it is now available without a prescription or "over the counter" (OTC) in a wide variety of formulations.
Desloratadine, the single active isomer of loratadine, was approved by the Food and Drug Administration (FDA) on December 21, 2001 and still requires a prescription.
Both versions are approved for pediatric use:
loratadine for children as young as 2 years of age and desloratadine for infants 6 months of age and older.
This issue of Pediatric Pharmacotherapy will provide a brief review of loratadine and desloratadine, focusing on studies supporting their use in the pediatric population.
  
Contraindications and Precautions
Loratadine and desloratadine are contraindicated in patients with a known sensitivity to either drug or the excipients used in the formulations available.
Hypersensitivity reactions are rare, but include rash, urticaria, pruritus, dyspnea, edema, and anaphylaxis.
Although some earlier second-generation antihistamines (astemizole, terfenadine) have been associated with prolongation of the QTc interval and a risk for torsades de pointes, multiple studies have shown no effect on ECG parameters by loratadine or desloratadine.
 
Drug Interactions
Drugs that inhibit the activity of CYP3A4, such as erythromycin, cimetidine, and ketoconazole, prolong the metabolism of loratadine and desloratadine. As a result, plasma concentrations may increase significantly. Administration of ketoconazole 200 mg every 12 hours produced a 307% increase in loratadine plasma concentrations, measured as the area under the concentration-time curve over 24 hours, and a 39% increase in desloratadine concentrations. In spite of the increase in plasma concentrations, studies conducted in healthy adult volunteers have not revealed a change in vital signs, electrocardiographic measurements of the QTc interval, laboratory tests, or other adverse effects.
Azithromycin and fluoxetine may also increase loratadine or desloratadine concentrations, but to a lesser degree.

Summary

Loratadine and desloratadine are effective therapies for the management of seasonal or perennial allergic rhinitis and urticaria in infants, children, and adults. As with other second generation antihistamines, their decreased potential for causing sedation compared to older agents, make loratadine and desloratadine first-line therapies for pediatric patients with allergies.

27 comments:

Anonymous said...

clomid cycle | clomid buy no prescription - has anyone bought clomid online, clomid for trt

Anonymous said...

clomid support | http://buyclomidonline.jimdo.com/#37911 - where to buy clomid and nolvadex, clomid days 3-7 when will i ovulate

Anonymous said...

clomid and late period | [url=http://buy-clomid-online.webs.com/#35996]buy clomid without prescription uk[/url] - clomid without prescriptions uk, jilg iui and clomid

Anonymous said...

clomid complications | buying clomid online safe - where can i buy clomid over the counter, clomid drug interactions

Anonymous said...

period after clomid cycle | where can i buy clomid - clomid online without prescription, clomid testosterone booster

Anonymous said...

clomid fertility drugs | http://cheapclomidonline.jimdo.com/#3349 - how much does clomid cost, taking clomid days 3-7

Anonymous said...

chances of twins on clomid | [url=http://buycheapclomid.webs.com/#21621]100mg clomid[/url] - best place to buy clomid, uhka where to get clomid

Anonymous said...

clomid ultrasound | clomid 100mg - i want to buy clomid online, femara clomid

Anonymous said...

clomid pregnancy rates | http://buy-clomid-in-usa.webs.com/#64361 - buy clomid online, male infertility clomid

Anonymous said...

clomid for pct | [url=http://buycheapclomid.jimdo.com/#15669]buy clomid online without rx[/url] - buy clomid no prescription uk, apin clomiphene citrate clomid side effects

Anonymous said...

clomid liquid | http://buyclomidonline.webs.com/#42169 - 100mg clomid, does clomid delay period

Anonymous said...

clomid testosterone | uses for clomid - cheap clomid online, clomid second round

Anonymous said...

what if clomid doesn't work | [url=http://orderclomid.jimdo.com/#2761]clomid dose[/url] - clomid purchase online, skgo arimidex vs clomid

Anonymous said...

clomid side effects after ovulation | [url=http://ordergenericclomid.webs.com/#43890]order clomid no prescription[/url] - purchase clomid without prescription, cgsa clomid uterine lining

Anonymous said...

Hi friends, how is the whole thing, and what you want to say about this piece of writing, in my view its genuinely awesome designed for me.


My web page: Pure Raspberry Ketones

Anonymous said...

http://site.ru - [url=http://site.ru]site[/url] site
site

Anonymous said...

Hello, i believe that i noticed you visited my
blog thus i got here to return the want?.I am trying to find issues to enhance my site!
I suppose its adequate to make use of some of your concepts!

!

Check out my web site; what is testosterone

Anonymous said...

It's great that you are getting ideas from this article as well as from our argument made at this time.

Also visit my web blog http://slimlipoplusdiet.com

Anonymous said...

Hiya very cool blog!! Guy .. Excellent ..
Wonderful .. I'll bookmark your web site and take the feeds also? I am glad to seek out so many useful info right here within the submit, we'd like develop extra strategies
in this regard, thank you for sharing. . . . .
.

my web-site http://datastream.info/wiki/DeborahoaDavisdf

Anonymous said...

Attractive portion of content. I just stumbled upon your website and in accession capital to assert that I get in fact loved account your weblog posts.
Any way I'll be subscribing on your feeds or even I success you get entry to persistently rapidly.

Here is my web site: http://datastream.info/wiki/DeborahoaDavisdf

Anonymous said...

Wonderful goods from you, man. I've understand your stuff previous to and you are just extremely great. I really like what you've acquired here, certainly like what you're stating and the way in which you say it. You make it entertaining and you still care for to keep it smart. I cant wait to read far more from you. This is really a tremendous site.

Feel free to surf to my webpage Full Piece of writing

Anonymous said...

My brother suggested I might like this blog.
He was totally right. This post actually made my day. You can not imagine just how much time I had spent for this info!
Thanks!

Also visit my site just click the following page

Anonymous said...

Hello! I'm at work browsing your blog from my new iphone 3gs! Just wanted to say I love reading through your blog and look forward to all your posts! Keep up the great work!

Feel free to visit my homepage :: http://trimextrindiet.com

Anonymous said...

whoah this blog is wonderful i like studying your articles.

Stay up the good work! You already know, many individuals are looking round for
this information, you could help them greatly.


Here is my website; Tostoboost Review

Anonymous said...

When I originally commented I seem to have clicked the -Notify me when new comments are added-
checkbox and from now on every time a comment is added I
recieve four emails with the exact same comment. Perhaps
there is a way you are able to remove me from that service?
Thanks!

Feel free to surf to my site :: losing weight help

Anonymous said...

Everyone loves what you guys are usually up too.
This type of clever work and reporting! Keep up the amazing works guys I've incorporated you guys to my own blogroll.

My web page :: St Cloud Floral

Anonymous said...

Cool blog! Is your theme custom made or did you download it from somewhere?
A design like yours with a few simple tweeks would really make my blog jump out.
Please let me know where you got your design.
Appreciate it

Here is my site :: breast massage therapy